“Kratom Alkaloids, Natural and Semi-Synthetic, Show Less Physical Dependence and Ameliorate Opioid Withdrawal” Published in the January 2021 issue of the journal Cellular and Molecular Neurobiology, new research reports that kratom may indeed be of clinical value for chronic opioid users. Regular opioid use and abuse produce physical dependence. Reducing intake after chronic use or …
“7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects” Kratom’s increase in popularity since the early 2000s has brought with it a great deal of misinformation and concern regarding “safe” use and “proper” dosage levels. This paper dives into the details, investigating how mitragynine and 7-hydroxymitragynine are metabolized and …
“The abuse potential of kratom according the 8 factors of the controlled substances act: implications for regulation and research.” Since the US Drug Enforcement Administration listed kratom as a “Drug of Concern” in 2008, scientists and advocates from around the globe have come together to prove otherwise. The DEA faced massive backlash in 2016 after …
“Following “the Roots” of Kratom (Mitragyna speciosa): The Evolution of an Enhancer from a Traditional Use to Increase Work and Productivity in Southeast Asia to a Recreational Psychoactive Drug in Western Countries.” A multinational interdisciplinary team of scholars provide a definitive roadmap of the history of kratom, beginning with the state of the art regarding …